Vol. 2026 No. 1 (2026)
Articles

Effects of Artesunate on the Biological Behavior of Lung Cancer A549 Cells

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  • Li Go,
  • Xiuying Zhang,
  • Catherine,
  • Alexander
Li Go
Beijing University of Traditional Chinese Medicine North Third Ring East Road Chaoyang District Beijing City China 100029
Xiuying Zhang
Nankai University Weijin Road Nankai District Tianjin City China 300071
Catherine
Nankai University Weijin Road Nankai District Tianjin City China 300071
Alexander
Harvard University Press 79 Garden Street Cambridge Massachusetts USA 02138

Published 28-02-2026

Keywords

  • Artesunate,
  • Lung cancer A549 cells,
  • Inhibition of cell proliferation,
  • Apoptosis,
  • Cell cycle arrest,
  • Cell migration,
  • Cell mechanical properties,
  • Cell membrane ultrastructure,
  • Antitumor effect
    • ...More
    Less

Copyright (c) 2026 Cambridge Science Advance

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
L. Go, X. Zhang, Catherine, and Alexander, “Effects of Artesunate on the Biological Behavior of Lung Cancer A549 Cells”, Camb. Sci. Adv., vol. 2026, no. 1, pp. 11–15, Feb. 2026, doi: 10.62852/csa/2026/220.

Abstract

At present, chemotherapy, one of the common treatment methods for lung cancer, has become far less effective due to drug resistance generated during treatment and the toxic and side effects of chemotherapeutic drugs themselves. This has made it an urgent task to find safer and more effective therapeutic drugs. Traditional Chinese medicine (TCM) is the essence of China's medical and pharmaceutical culture, and the anti-tumor effects of TCM preparations have attracted increasing attention. In this study, human lung cancer A549 cells were used as the research object. Different concentrations of artesunate (Art) were added, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, Trans-well migration and invasion assay, combined with atomic force microscope (AFM), were used to observe the effects of Art on cell proliferation, cell cycle, migration, cell mechanical properties and surface ultrastructure. The aim was to provide effective scientific basis for the anti-lung cancer mechanism of Art.

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