Vol. 2026 No. 1 (2026)
Articles

Expression of mismatch repair gene proteins in endometrial complex hyperplasia

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  • Jingyi Liu,
  • Ran Chen
Jingyi Liu
Tongji University, Si ping Road, Yangpu District, Shanghai, Shanghai, China, 200092
Ran Chen
Tongji University, Si ping Road, Yangpu District, Shanghai, Shanghai, China, 200092

Published 28-02-2026

Keywords

  • Endometrial Complex Hyperplasia,
  • Mismatch Repair,
  • Gene Expression

Copyright (c) 2026 Cambridge Science Advance

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
. J. Liu and R. Chen, “Expression of mismatch repair gene proteins in endometrial complex hyperplasia”, Camb. Sci. Adv., vol. 2026, no. 1, pp. 22–25, Feb. 2026, doi: 10.62852/csa/2026/222.

Abstract

Objective To observe the expression of mismatch repair gene proteins in endometrial complex hyperplasia. Methods A total of 50 pathological tumor specimens from patients with endometrial complex hyperplasia were collected. Immunohistochemical detection was performed on the pathological tissues. Clinical information was obtained from medical records for analysis. Results Among the 50 patients with endometrial complex hyperplasia, 27 cases (54%) showed deletion of at least one mismatch repair gene expression, 18 cases (36%) showed deletion of two or more mismatch repair gene expressions, and 3 cases (6%) showed negative expression of all four mismatch repair genes. Conclusion More comprehensive genetic testing should be performed for patients with endometrial complex hyperplasia, so as to provide an effective means for the prevention of endometrial carcinoma.

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