Published 13-09-2024
Keywords
- Cornus officinalis,
- Chemical Components,
- Pharmacological Effects
Copyright (c) 2024 Cambridge Science Advance
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Abstract
This article reviews the chemical components and pharmacological effects of Cornus officinalis Sieb.et Zucc., a traditional Chinese medicinal herb that contains a variety of active ingredients, including iridoid glycosides, flavonoids, organic acids, and tannins. These components endow Cornus officinalis with multiple pharmacological actions, such as neuroprotection, anti-diabetes and its complications, cardioprotection, anti-tumor, and antioxidant effects. In particular, the paper discusses the impact of Cornus officinalis iridoid glycosides on learning and memory ability after cerebral ischemia, as well as their potential mechanisms in the treatment of diabetic nephropathy. Additionally, the application of Cornus officinalis methanol extract in promoting melanin synthesis and its anti-inflammatory, anti-fatigue, antibacterial, anti-osteoporotic, and hepato- and reno-protective effects are also discussed. Although progress has been made in existing research, the specific roles and mechanisms of some newly discovered compounds in Cornus officinalis still require further investigation. This paper aims to provide a reference for in-depth research and clinical application of Cornus officinalis.
References
- Ma ZY, Yao BH, Wang LJ, et al. Chemical constituents from Cornus officinalis and their biological activity[J]. Chronicles of Young Scientists,2012, 3(3):209-211. DOI: https://doi.org/10.4103/2229-5186.99579
- Zhang Yue' e, Liu Ehu, Li Hui Jun, et al. Chemical Components of Cornus officinalis [J]. Chinese Journal of Natural Medicines,2009,7(5):365-367. DOI: https://doi.org/10.3724/SP.J.1009.2009.00365
- Wang Y, Li ZQ, Chen LR, et al. Antiviral compounds and one new iridoid glycoside from Cornus officinalis[J]. Progress in Natural Science,2006,16(2): 142-146. DOI: https://doi.org/10.1080/10020070612331343205
- Liang JR, He J, Zhu S, et al. Preparation of main iridoid glycosides in Fructus Corni by macroporous resin column chromatography and countercurrent chromatography[J]. Journal of Liquid Chromatography& Related Technologies, 2013,36(8):983-999. DOI: https://doi.org/10.1080/10826076.2012.683914
- Li Yamei, Li Hua, Li Chun Rong, et al. Research Progress on Chemical Components and Pharmacological Effects of Cornus officinalis [J]. Journal of the People's Armed Police Medical College,2010,16(6):500-502.
- Zhang LL, Wang YM, Xu M, et al. Quantification of gallic acid and ellagic acid from the seed of Cornus officinalis by UHPLC method and their antioxidant activity[J]. Chemical Engineering Communications,2014,201(4):545-556. DOI: https://doi.org/10.1080/00986445.2013.780165
- Liu Bo, Wu He Zhen. Research on Triterpenoid Components in Cornus officinalis Medicinal Materials [J]. Hubei Journal of Traditional Chinese Medicine,2010,32(12):75-76.
- Yamabe N, Kang KS, Matsuo Y, et al. Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hechimi jiogan, in streptozotocin induced diabetic rats[J]. Biological & Pharmaceutical Bulletin, 2007,30(7):1289-1296. DOI: https://doi.org/10.1248/bpb.30.1289
- Ding Yu Xia, Zhang Li, Ye Cui Fei, et al. The influence of Cornus officinalis iridoid glycosides on neuron survival and apoptosis-related factors in the hippocampal region of rats after transection of the fornix fimbria [J]. Journal of Capital Medical University, 2011, 32(1): 73-78.
- Cai Xiaojun, Shao Nan qi, Song Hui Zhu, et al. Research progress on the brain-protective effects and molecular mechanisms of the main active components of Cornus officinalis [J]. Chinese Journal of Biochemical Pharmaceutics, 2015, 35(1): 181-184.
- Wu Hui, Yu Rong, Cheng Xi Hua, et al. Study on the intervention of insulin signaling pathway by Jiang tang Yishen prescription in improving kidney damage in transgenic type 2 diabetic MKR rats [J]. Journal of Hunan University of Chinese Medicine, 2011, 31(11): 9-11.
- Huang Ping, Chen Dan, Hua Jian, et al. Effect of Cornus officinalis granules on the TGF-β1/Smad7 pathway in diabetic nephropathy rats [J]. Chinese Journal of Integrated Medicine on Kidney Diseases, 2012, 13(9): 762-764.
- Yang Yong, Rong Rong, Jiang Chun Hong, et al. Study on the hypoglycemic effect of different polarity extracts of Cornus officinalis [J]. Liaoning Journal of Traditional Chinese Medicine, 2011, 38(1): 170-171.
- Tang Zhi Shu, Guo Liwei, Wang Bin, et al. Study on the protective effect of Panax no to ginseng saponins/Cornus officinalis total saponins on ischemic myocardium of dogs with coronary artery ligation [J]. Shi Zhen Guo Yi Guo Yao, 2011, 22(1): 72-74.
- Chen Ke fang, Li Jianjun, Pan Ai Zhen, et al. Study on the intervention of Cornus officinalis total glycosides in apoptosis of myocardial cells in acute hypoxic suckling mice [J]. Journal of Traditional Chinese Medicine and Western Medicine, 2012, 10(12): 1488-1489.
- Zou Pin wen, Zhao Chun Jing, Li Pan, et al. Antitumor effect and immune mechanism of polysaccharides from Cornus officinalis [J]. Chinese Hospital Pharmacy Journal, 2012, 32(1): 20-22.
- Chen Yu Xia, Liu Jianhua, Lin Feng, et al. Determination of antioxidant activity of 41 kinds of traditional Chinese medicinal herbs by DPPH and FRAP methods [J]. Research and Exploration in Laboratory, 2011, 30(6): 11-14.