Vol. 2024 No. 4 (2024)
Articles

Determination of sodium and potassium in Dan Hong injection by atomic absorption spectrometry

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  • Yun Wang,
  • Qingguo Liu,
  • Zhu Yangbang,
  • Ling Xue
Yun Wang
Qingdao Academy of Chinese Medicine Sciences, Buil ding 3, Qingdao Blue Bio-Pharmaceutical Industrial Park, No. 368 He Dong Road, High-Tech Zone, Qingdao City, Shandong Province, Postal Code: 266112, China.
Qingguo Liu
Qingdao Academy of Chinese Medicine Sciences, Buil ding 3, Qingdao Blue Bio-Pharmaceutical Industrial Park, No. 368 He Dong Road, High-Tech Zone, Qingdao City, Shandong Province, Postal Code: 266112, China.
Zhu Yangbang
Qingdao Academy of Chinese Medicine Sciences, Buil ding 3, Qingdao Blue Bio-Pharmaceutical Industrial Park, No. 368 He Dong Road, High-Tech Zone, Qingdao City, Shandong Province, Postal Code: 266112, China.
Ling Xue
Key Laboratory of Drug Formulation Technology Research and Evaluation, National Medical Products Administration, No. 27 Shanda South Road, Jinan City, Shandong Province, Postal Code: 250100, China.

Published 13-09-2024

Keywords

  • Dan Hong injection,
  • sodium ion,
  • potassium ion,
  • atomic absorption spectrometry

Copyright (c) 2024 Cambridge Science Advance

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
Y. Wang, Q. Liu, Z. Yangbang, and L. Xue, “Determination of sodium and potassium in Dan Hong injection by atomic absorption spectrometry”, Camb. Sci. Adv., vol. 2024, no. 4, pp. 7–12, Sep. 2024, doi: 10.62852/csa/2024/62.

Abstract

To establish and validate the determination method of the content of sodium ion and potassium ion in Dan Hong injection by atomic absorption spectrometry (AAS). [Methods] Microwave digestion system was applied to deteriorate samples, and the content of sodium ion and potassium ion was determined by AAS. [Results] The calibration curve of sodium was liner (r=0.9998) in the range from 0.1to0.6mg/L. The average recovery was 101.1% with RSD 1.8%. The limit of detection was 5.3μg/L. The calibration curve of potassium was liner (r=0.9998) in the range from 0.1 to 0.8mg/L. The average recovery was 99.8%with RSD 2.3%. The limit of detection was 7.7μg/L. The determination results of 10 batches Dan Hong injection sample showed that the content of sodium ion was 562.3 to 734.7 mg/L and potassium ion was 206.9 to 314.4mg/L. [Conclusion] The method is simple and accurate and can be used for determination of the contents of sodiumion and potassium ion in Dan Hong injection. The accurate quantitative determination method can be promoted to quality control of Dan Hong injection

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References

  1. National Pharmacopoeia Commission, ed. Chinese Pharmacopoeia (Part I) [S]. Beijing: Chemical Industry Press, 2010: Appendix IXS.
  2. Dai Shuchun, Song Jun, Zhou Hua sheng, et al. Interference and Elimination of Potassium and Sodium in Special Medical Formula Foods Measured by Flame Atomic Absorption Method [J]. Food Industry Technology, 2014, 35(9): 303-306.
  3. Liu Xiu Shu, Du Qian, Yin Shi Qiang. Two cases of hyperkalemia caused by traditional Chinese medicine in patients with chronic renal failure [J]. Tianjin Pharmacy, 2015, 27(2): 55-56.
  4. Tong Dan Hong, Chen Quan Yong, Wu Xiaole. Comparative Analysis of Potassium and Sodium Ion Levels in Arterial and Venous Blood [J]. Chinese Rural Medicine, 2014, 21(13): 54-55.
  5. Shi Wei, L v Pengfei, Liu Ran, et al. The Impact of Traditional Chinese Medicine Compound on Serum Potassium Concentration in the Treatment of Chronic Renal Failure [J]. China Pharmacy, 2015, 24(8): 37-39.
  6. Zhu Ping Xian, Li Ming. Research Progress on the Impact of Potassium Metabolism on Cardiac Arrhythmias [J]. Cardiovascular Disease Prevention and Treatment Knowledge (Academic Edition), 2011, 4(2): 84-85.
  7. Nie Li Xing, Jin Hongyu, Lin Rui chao, et al. Determination of Potassium Content in Carthamus Tinctorius L. Injection by Atomic Absorption Spectrophotometry [J]. Journal of Pharmaceutical Analysis, 2010, 30(3): 468-470.
  8. Ning Hong Xin, Wang Wei, Yang Ying, et al. Determination of Sodium, Potassium, and Magnesium Ions in Compound Electrolyte Injection by Flame Atomic Absorption Spectrophotometry [J]. Drug Evaluation Research, 2011, 34(4): 267-269.
  9. Ren Liping, Deng Lijuan, Fan Hui Hong. Determination of Sodium and Potassium Ions in Calf Blood Protein Extract Concentrate by Flame Atomic Absorption Method [J]. Journal of Pharmaceutical Analysis, 2014, 34(4): 636-638.
  10. Tang Wei, Sun Xiaoyi. Determination of Potassium in Precipitation by Flame Atomic Absorption Method Using Ionization Suppressor [J]. Heilongjiang Environmental Bulletin, 2002, 26(4): 89-90.
  11. Jiang Yucheng, Hu Man Cheng, Gao Shi yang, et al. Atomic Absorption Analysis of Alkali Metal Impurities in High Purity Cesium Chloride [J]. Laboratory of Analysis and Test, 2004, 23(3): 77-79.
  12. Liu Dong, Zhang Chang, Yang Shi Kun. Method Study on Determination of Trace Sodium and Potassium Ions in Calcium Stearate by Atomic Absorption Method [J]. Journal of Southwest University for Nationalities (Natural Science Edition), 2002, 28(2): 234-235.
  13. Zhang Guo Yue, Song Li, Fan Bao Juan, et al. Investigation of Test Conditions for Determination of Chromium in Gelatin Capsules by Microwave Digestion-Atomic Absorption Spectrophotometry [J]. Journal of Pharmaceutical Analysis, 2012, 32(8): 1328-1330.
  14. Tan He ping, L v Hao, Gao Yang, et al. Application of Microwave Digestion in the Analysis of Rare Earth Elements and Heavy Metals in Tea and Soil [J]. China Testing, 2010, 36(2): 37-40.
  15. Miao Lixin. Determination of Zinc in Fortified Foods by Microwave Digestion-Flame Atomic Absorption Spectrometry [J]. Henan Preventive Medicine, 2015, 26(3): 187-188.