Vol. 2024 No. 4 (2024)
Articles

TCM in post stroke brain remodeling: Research advances

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  • Oliver Thomas,
  • Jacob Anderson
Oliver Thomas
University College London, Gower St, Bloomsbury, London WC1E 6BT, United Kingdom
Jacob Anderson
University College London, Gower St, Bloomsbury, London WC1E 6BT, United Kingdom

Published 13-09-2024

Keywords

  • Traditional Chinese Medicine,
  • Stroke,
  • Brain Functional Remodeling,
  • Review

Copyright (c) 2024 Cambridge Science Advance

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
O. Thomas and J. Anderson, “TCM in post stroke brain remodeling: Research advances”, Camb. Sci. Adv., vol. 2024, no. 4, pp. 24–33, Sep. 2024, doi: 10.62852/csa/2024/65.

Abstract

Brain functional remodeling is fundamental to the recovery from stroke and is one of the hot topics in modern brain science research, involving various factors such as neurophysiology, neurochemistry, and neuroimaging. Traditional Chinese Medicine (TCM), with its multi-target and multi-stage effects on the body, has unique advantages in improving neurological functions and promoting brain functional remodeling. Current research mainly focuses on monotherapy with Chinese herbs, compound prescriptions, and acupuncture, among other aspects. This paper summarizes their effects and related mechanisms, aiming to provide theoretical support for the clinical application of TCM in promoting brain function recovery after stroke.

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References

  1. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010[J]. The Lancet,2013,380(9859):2095-2128.
  2. Wang Wen Zhi. Current Status and Development Direction of Cerebrovascular Disease Prevention and Treatment Research in China [J]. Chinese Journal of Modern Neurology, 2011, 11(2): 134-137.
  3. Stroemer RP, Kent TA, Hulsebosch CE. Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats[J]. Stroke.1995,26(11): 2135-2144.
  4. Li Peng Tao. Prospects for Research on the Role of Traditional Chinese Medicine in Inducing Neuronal Plasticity Changes for Brain Function Recovery [J]. Journal of Beijing University of Chinese Medicine, 2002, 25(1): 1-4.
  5. Ding Y, Li J, Clark J, et al. Synaptic plasticity in thalamic nuclei enhanced by motor skill training in rat with transient middle cerebral artery occlusion[J]. Neurological Research,2003,25(2):189-194.
  6. Valtorta F, Pennuto M, Bonanomi D, et al. Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis[J]. Bioessays,2004,26(4):445-453.
  7. Yan BC, Park JH, Ahn JH, et al. Postsynaptic density protein (PSD)-95 expression is markedly decreased in the hippocampal CAI region after experimental ischemia-reperfusion injury[J]. Journal of the Neurological Sciences,2013,330(1-2):111-116.
  8. Benowitz LI, Routtenberg A.GAP-43:an intrinsic determinant of neuronal development and plasticity[J]. Trends in Neuroscience, 1997,20(2):84-91.
  9. Madinier A, Bertrand N, Mossiat C, et al. Microglia involvement in neuroplastic changes following focal brain ischemia in rats[J]. PL o S One,2009,4(12): e8101.
  10. Sá n chez C, D í a z Ni do J, Avila J. Phosphorylation of microtubule-associated protein 2(MAP2) and its relevance for the regulation of the neuronal cytoskeleton function [J]. Progress in Neurobiology,2000,61(2):133-168.
  11. LIT, MOX, JIANGZ, et al. Study of α B-crystallin expression in Gerbil BCA0 model of transient global cerebral ischemia[J]. Oxid Med Cell Longev,2012,2012:945071.
  12. S chäbitz WR, Steigleder T, Cooper-Kuhn CM, et al. Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis[J]. Stroke,2007,38(7): 2165-2172.
  13. Mattson MP. Glutamate and neurotrophic factors in neuronal plasticity and disease[J]. Annals New York of Academy of Sciences,2008,1144:97-112.
  14. Moubarak RS, Sole C, Pascual M, et al. The death receptor antagonist FLIP-L interacts with Trk and is necessary for neuriteoutgrowth induced by neurotrophins[J]. Journal of Neuroscience,2010,30(17): 6094-6105.
  15. Karatzas A, Katsanos K, Lilis I, et al. NGF promotes hemodynamic recovery in a rabbit hindlimb ischemic model throughtrk A-and VEGFR2-dependent pathways[J]Joumal of Cardiovascular Pharmacology,2013,62(3):270-277.
  16. [16] CHINF, LIU HL, YANG JT, et al. Neuroprotective mechanism of BNG-1 against focal cerebral is chemia: aneuro imaging and neurotrophin study[J]. P Lo S One,2014,9(12): e114909.
  17. Gao Zhenzhen, Guo Hai ying, Wang Zun, et al. Advances in Molecular Mechanism Research on the Impact of Motor Therapy on Brain Functional Remodeling [J]. Journal of Stroke and Rehabilitation Medicine, 2013, 28(10): 980-984.
  18. Herz J, Reitmeir R, Hagen SI, et al. Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving antiinflammatory actions[J]. Neurobiology of Disease,2012,45(3): 1077-1085.
  19. Zhao Zhe, Deng Qi Yue. The Role of No go -A in Regeneration and Development After Central Nervous System Injury [J]. Journal of Local Surgery, 2012, 21(6): 659-661.
  20. Pekna M, Pekny M, Nilsson M. Modulation of neural plasticity as a basis for stroke rehabilitation[J]. Stroke ,2012,43(10): 2819-2828.
  21. Yan Yongxing, Liang Li Zhen, Zhou Zhilin, et al. The Impact of Panax No to ginseng Saponins on Cerebral Infarction Volume and No go -A Expression at Different Recovery Stages After Focal Cerebral Ischemia-Reperfusion in Rats [J]. Chinese Journal of Traditional Chinese Medicine and Science and Technology, 2010, 17(5): 407-408.
  22. Cui Fang yuan, Zhai Jian ying, Zou Wei meng, et al. The Influence of San qi Tong Shu Capsule on the Expression of S y p and PSD-95 at Different Recovery Time Points After Cerebral Infarction [J]. Chinese Patent Medicine, 2008, 30(1): 31-34.
  23. Luo Yong Jie, Wang Xiaoping. The Influence of San qi Tong Shu Capsule on the Expression of Serum VEGF and IL-6 at Different Time Points of Acute Cerebral Infarction [J]. Chinese Journal of Evidence-Based Medicine, 2010, 10(10): 1155-1158.
  24. Xie Hongmei. The Efficacy of San qi Tong Shu Capsule on Middle-Aged and Elderly Patients with Ischemic Stroke and Its Impact on Insulin-Like Growth Factor-1 and Matrix Metalloproteinase-9 in Serum [J]. Chinese Journal of Gerontology, 2013, 33(2): 433-434.
  25. Xu Shi Cheng. Ingenious Use of Ephedra to Treat Intractable Diseases [J]. Shanghai Journal of Traditional Chinese Medicine, 2001, 35(7): 8-9.
  26. Zhao Xiao Ke, Xiao Nong, Zhou Jiang bao, et al. Cellular and Molecular Mechanisms of Ephedrine Promoting Motor Function Recovery in Rats with Cerebral Ischemia [J]. Journal of the Fourth Military Medical University, 2007, 28(3): 240-243.
  27. Shen Ya Ning. Clinical Observation of Shu Luo Pian in Treating the Recovery Period of Stroke with Blood-Heat and Blood-Stasis Syndrome (Cerebral Infarction) [D]. Wuhan: Hubei University of Chinese Medicine, 2006.
  28. Deng Chang. The Impact of Xue Shuan tong Injection on NGF and TrkA in the Cortex of Focal Cerebral Ischemia-Reperfusion [J]. Contemporary Medicine, 2009, 15(10): 29-31.
  29. Xie Li, Liu Fu you. The Influence of Shen Mai Injection on the Expression of GAP-43 and SYP Proteins After Cerebral Infarction in Rats [J]. Shaanxi Journal of Traditional Chinese Medicine, 2011, 32(9): 1255-1257.
  30. Xie Li, Liang Jing Tao, Tian Rong ren, et al. The Influence of Shen Mai Injection on the Expression of BDNF mRNA and No go-A mRNA in Rats with Cerebral Ischemia [J]. Shaanxi Journal of Traditional Chinese Medicine, 2010, 31(1): 121-123.
  31. Ma Dai chao, Chen Wei yin, Li Hong gang, et al. The Impact of Shen Xiong Diwan on Neuroplasticity After Cerebral Ischemia-Reperfusion in Rats [J]. Chinese Patent Medicine, 2012, 34(5): 814-818.
  32. Zhou Yong Hong. Clinical Study of 30 Cases Treated with Fu ken Capsule for Ischemic Stroke [J]. Journal of Traditional Chinese Medicine, 2002, 43(5): 355-356.
  33. Hu Huai Qiang, Zhou Yong Hong, Ma Xue sheng, et al. The Impact of Fu ken Pian on the Expression of No go-A at Different Time Points After Cerebral Infarction in Rats [J]. Chinese Journal of Experimental Animals, 2010, 18(2): 118-121.
  34. Zhou Yong Hong, Hu Huai Qiang, Wang Xin Lu. The Effect of Fu ken Pian on Promoting Motor Function Recovery and Neuronal Regeneration in Rats with Cerebral Infarction [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2013, 33(1): 100-104.
  35. Liu Shu Quan, Jin Yan, Meng Xian sheng, et al. The Impact of Kai Qiao Tong fu Tang on the Expression of Endothelial Growth Factor Protein in Brain Tissue of MCAO Rats [J]. Journal of Traditional Chinese Medicine and Western Medicine, 2008, 6(9): 1052-1053.
  36. Liu Hui Xian, Liu Jing Xia, Yu Wei, et al. The Influence of Bu yang Huan Wu Tang and Xing Wei Cheng qi Tang on Synaptic Remodeling of Neurons and the Expression of Glial Cell Line-Derived Neurotrophic Factor and Nerve Growth Factor in Rats with Cerebral Ischemia [J]. Chinese Journal of Gerontology, 2015, 35(3): 702-705.
  37. Tang Ying Hong, Li Hua, Chen Bei yang, et al. The Effect of Effective Parts of Bu yang Huan Wu Tang on the Expression of Caspase After Focal Cerebral Ischemia-Reperfusion [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2006, 26(6): 533-537.
  38. Liu Hongwei, Li Kang Shi, Zhang Yong, et al. Correlative Study on the Impact of Acupuncture at Yang ling Quan and Passive Finger Movement on Motor Brain Area Based on Functional Imaging [J]. China Journal of Traditional Chinese Medicine and Pharmacy (formerly China Medical Journal), 2015, 30(5): 1443-1446.
  39. XIE Z, CUI F, Z0U Y, et al. Acupuncture enhances effective connectivity between cerebellum and primary sensorimotor cortex in patients with stable recovery stroke[J]. Evidence Based Complementary and Alternative Medicine,2014,2014: e603909.
  40. Si Wei Jun, Zhang Hua, Wang Peng, et al. Observation on the Immediate Effect of Acupuncture at Yang ling Quan on Passive Movement in Patients with Cerebral Infarction [J]. Chinese Acupuncture & Moxibustion, 2013, 33(2): 131-136.
  41. ZHANG Y, LI K, REN Y, et al. Acupuncture modulates the functional connecivity of the defaultmode network in stroke patients[J]. Evidence Based Complementary and Alternative Medicine,2014,2014: e765413.
  42. Cui Fang yuan, Zou Yihua, Tan Zhong Jian, et al., fMRI and DTI Study on the Recovery of Motor Function and the Therapeutic Effect Level of Scalp Acupuncture in Stroke Hemiplegia [J]. Journal of Beijing University of Chinese Medicine (Clinical Edition), 2013, 20(4): 34-38.
  43. Shen Zai yin, Research on the Mechanism of Brain Functional Remodeling after Scalp Acupuncture Treatment for Stroke Hemiplegia Using Functional Magnetic Resonance Imaging (fMRI) [D]. Beijing: Beijing University of Chinese Medicine, 2013.
  44. Ni Jin Xia, Zhu Wen Zeng, Yu Zhi shun, The Influence of the Cluster Needling Method on the Pathomorphology and Apoptosis-Related Gene Caspase-3 in Rats with Acute Cerebral Infarction [J]. Shanghai Journal of Acupuncture and Moxibustion, 2008, 27(9): 43-45.
  45. Zhu Wen Zeng, Ni Jin Xia, Tang Qiang, et al., The Influence of the "Cluster Needling Method on the Head Points" on the Plasticity Protein MAP-2 in Rats with Focal Cerebral Infarction [J]. Chinese Acupuncture & Moxibustion, 2010, 30(1): 46-50.
  46. Zhou Yuan Cheng, Wu Xin Guo, Xiao Yicai, The Influence of Electroacupuncture Stimulation of "Zu San Li" and "Nei Guan" on the Expression of GAP-43 in Rats with Cerebral Infarction [J]. Chinese Acupuncture & Moxibustion, 2011, 31(1): 55-59.
  47. Han Yong sheng, Xu Yin, Han Yong Zhu, et al., The Influence on the Motor Function and Neural Plasticity in Rats with Focal Cerebral Ischemia-Reperfusion [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2013, 15(8): 92-97.
  48. Han Xiaohua, Huang Xiaolin, Wang Yi Zhao, et al., The Influence of Electroacupuncture Combined with Repetitive Transcranial Magnetic Stimulation on Synaptophysin in the Hippocampus of Rats with Cerebral Ischemia [J]. Chinese Journal of Rehabilitation Medicine, 2009, 24(12): 1057-1060.
  49. Jin He, Functional Magnetic Resonance (fMRI) Study on the Improvement of Upper Limb Muscle Tone in Stroke by Point Pressing at He Gu Point [D]. Beijing: Beijing University of Chinese Medicine, 2013.
  50. Wang Chun, Guo Zhi Xue, Li Ou, The Influence of Thrombolytic Acupoint Injection on the Clinical Efficacy and Quality of Life in Patients in the Recovery Period of Stroke [J]. Chinese Rehabilitation, 2009, 24(3): 177-179.